Medicamentos peligrosos: resumen normativo

Autores/as

  • Mª Ángeles Bernabeu Martinez Hospital Universitario de San Juan de Alicante. Servicio de Farmacia. Alicante

DOI:

https://doi.org/10.22585/hospdomic.v8i1.210

Palabras clave:

Agentes Antineoplásicos, Agentes Citostáticos,, Sustancias Peligrosas, Seguridad del Paciente, Salud laboral

Resumen

Las propiedades tóxicas de los medicamentos citostáticos son bien conocidas desde que en los años 40 empezaron a utilizarse en el ámbito oncológico.

Descargas

Los datos de descargas todavía no están disponibles.

Citas

Goodman LS, Wintrobe MM. Nitrogen mustard therapy; use of methyl-bis (beta-chloroethyl) amine hydrochloride and tris (beta-chloroethyl) amine hydrochloride for Hodgkin’s disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders. J Am Med Assoc. 1946; 132(3):126-32. DOI: 10.1001/jama.1946.02870380008004

Falck K, Gröhn P, Sorsa M, Vainio H, Heinonen E, Holsti LR. Mutagenicity in urine of nurses handling cytostatic drugs. Lancet. 1979;1(8128):1250-1. DOI: 10.1016/S0140-1696736(79)91939-1

Norppa H, Sorsa M, Vainio H, Gröhn P, Heinonen E, Holsti L, et al. Increased sister chromatid exchange frequencies in lymphocytes of nurses handling cytostatic drugs. Scand J Work Environ Health. 1980;6(4):299-301. DOI: 10.5271/sjweh.2605

Anderson RW, Puckett WH, Dana WJ, Nguyen TV, Theiss JC, Matney TS. Risk of handling injectable antineoplastic agents. Am J Hosp Pharm. 1982;39(11):1881-7. PMID: 6756133

Waksvik H, Klepp O, Brøgger A. Chromosome analyses of nurses handling cytostatic agents. Cancer Treat Rep. 1981;65(7-8):607-10. PMID: 7248981

Nikula E, Kiviniitty K, Leisti J, Taskinen PJ. Chromosome aberrations in lymphocytes of nurses handling cytostatic agents. Scand J Work Environ Health. 1984;10(2):71-4. DOI: 0.5271/sjweh.2355

Guidelines for safe handling of cytotoxic drugs in pharmacy departments and hospital wards. Hosp Pharm. 1981;16(1):17-20. PMID: 10249749

American Society of Hospital Pharmacists (ASHP). ASHP technical assistance bulletin on handling cytotoxic and hazardous drugs. Am J Hosp Pharm. 1990;47(5):1033-49. PMID: 2186621

Yodaiken R, Bennett D. OSHA work-practice guidelines for personnel dealing with cytotoxic (antineoplastic) drugs. Am J Hosp Pharm. 1986;43(5):1193-204. PMID: 3717176

Burroughs G, Connor T, McDiarmid M. NIOSH Alert: preventing occupational exposures to antineoplastic and other hazardous drugs in health care settings [Monografía de Internet]. Atlanta, USA: National Institute of Occupational Safety and Health (NIOSH), Department of Health and Human Services, Center for Disease Control and Prevention; 2004 Report: 2004–165 [citado 29 de enero 2024]. Disponible en: https://goo.gl/PoEScK

National Institute of Occupational Safety and Health (NIOSH). NIOSH list of antineoplastic and other hazardous drugs in healthcare settings 2010 [Monografía de Internet]. Atlanta, USA: National Institute of Occupational Safety and Health (NIOSH), Department of Health and Human Services, Center for Disease Control and Prevention,; 2010. [citado 29 de enero de 2024]. Report No.: 2010-167. Disponible en: http://bit.ly/3zNtzw1

Connor T, MacKenzie B, DeBord D, Trout D, O’Callaghan J. NIOSH List of Antineoplastic and Other Hazardous Drugs in Healthcare Settings, 2012 [Monografía de Internet]. Atlanta, USA: National Institute of Occupational Safety and Health (NIOSH), Department of Health and Human Services, Center for Disease Control and Prevention,; 2012 [citado 29 de enero de 2024]. Report No.: 2012-150. Disponible en: http://bit.ly/3mtA4B1

Connor T, MacKenzie B, DeBord D, Trout D, O’Callaghan J. NIOSH list of antineoplastic and other hazardous drugs in healthcare settings 2014 [Monografía de Internet]. Atlanta, USA: National Institute of Occupational Safety and Health (NIOSH), Department of Health and Human Services, Center for Disease Control and Prevention; 2014 [citado 29 de enero de 2024]. Report No.: 2014-138. Disponible en: https://bit.ly/3KMJIZ4

Connor T, MacKenzie B, DeBord D, Trout D, O’Callaghan J. NIOSH List of Antineoplastic and Other Hazardous Drugs in Healthcare Settings, 2016 [Monografía de Internet]. Atlanta, USA: National Institute of Occupational Safety and Health (NIOSH), Department of Health and Human Services, Center for Disease Control and Prevention,; 2016 [citado 29 de enero de 2024]. Report No.: 2016-161. Disponible en: http://bit.ly/3KnZ4ln

Connor T, MacKenzie B, DeBord D, Trout D, O’Callaghan J, Ovesen, JL. NIOSH List of Antineoplastic and Other Hazardous Drugs in Healthcare Settings, 2020 [Monografía de Internet]. Atlanta, USA: National Institute of Occupational Safety and Health (NIOSH), Department of Health and Human Services, Center for Disease Control and Prevention; 2020 [citado 29 de enero de 2024]. Report No.: 2020-xxx. Disponible en: https://bit.ly/400Pzyd

Jong T de, Pawlowska-Cyprysiak K, Hildt-Ciupińska K, Bos E, Nicolescu G, Trifu A, et al. Current and emerging occupational safety and health (OSH) issues in the healthcare sector, including home and community care: European Risk Observatory Report. Luxembourg: European Union Publications Office; 2014 [citado 29 de enero de 2024]. Disponible en: https://goo.gl/FMcZmG

Herrero Alonso JM, Gaspar Carreño M, Cercós Lleti AC. Medicamentos peligrosos: una carrera de fondo. Rev OFIL. 2018;28(1):9-10.

Krstev S, Perunicić B, Vidaković A. Work practice and some adverse health effects in nurses handling antineoplastic drugs. Med Lav. 2003;94(5):432-9. PMID: 14619181

Crudi CB, Stephens BL, Maier P. Possible occupational hazards associated with the preparation/administration of antineoplastic agents. NITA. 1982;5(4):264-5. PMID: 6922411

Curran CF, Luce JK. Ocular adverse reactions associated with adriamycin (doxorubicin). Am J Ophthalmol. 1989;108(6):709-11. PMID: 2596552

Valanis BG, Vollmer WM, Labuhn KT, et al. Association of antineoplastic drug handling with acute adverse effects in pharmacy personnel. Am J Hosp Pharm. 1993;50:455-62. PMID: 8442461

McDiarmid M, Egan T. Acute occupational exposure to antineoplastic agents. J Occup Med. 1988;30:984-7. PMID: 3230452

Anderson RW, Puckett WH, Dana WJ, Nguyen TV, Theiss JC, Matney TS. Risk of handling injectable antineoplastic agents. Am J Hosp Pharm. 1982;39(11):1881-7. PMID: 6756133

Nguyen TV, Theiss JC, Matney TS. Exposure of pharmacy personnel to mutagenic antineoplastic drugs. Cancer Res. 1982;42(11):4792-6. PMID: 6751527

Selevan SG, Lindbohm ML, Hornung RW, Hemminki K. A study of occupational exposure to antineoplastic drugs and fetal loss in nurses. N Engl J Med. 1985;313(19):1173-8. PMID: 4058490

Hemminki K, Kyyrönen P, Lindbohm ML. Spontaneous abortions and malformations in the offspring of nurses exposed to anaesthetic gases, cytostatic drugs, and other potential hazards in hospitals, based on registered information of outcome. J Epidemiol Community Health. 1985;39(2):141-7. PMID: 3925060

Sessink PJ, Kroese ED, van Kranen HJ, Bos RP. Cancer risk assessment for health care workers occupationally exposed to cyclophosphamide. Int Arch Occup Environ Health. 1995;67(5):317-23. PMID: 8543380

Instituto Nacional de Seguridad e Higiene en el Trabajo (INSHT). Guía técnica para la evaluación y prevención de los riesgos relacionados con la exposición durante el trabajo a agentes cancerígenos y mutágenos [Monografía de Internet]. Madrid, España: INSHT; 2009 [citado el 29 de enero de 2024]. Disponible en: https://goo.gl/VPudgZ

Valero García S, López Bri E, Vila Clérigues N, Poveda Andrés JL. Medicamentos biopeligrosos: nuevos retos, nuevas oportunidades. Farm Hosp. 2016;40(2):124-30. DOI: 10.7399/fh.2016.40.2.10462

Erce A, editor. Preventing occupational exposure to cytotoxic and other hazardous drugs. European Policy Recommendations. [Monografía de Internet]. Bruselas, Bélgica: Rohde Public Policy; 2016 [citado el 3 de abril de 2023]. Disponible en: https://bit.ly/2qXKWHG

Comisión Europea. Marco estratégico de la UE en materia de salud y seguridad en el trabajo 2021-2027 [Monografía de Internet]. Bruselas, Bélgica: Comisión Europea; 2021. [citado 29 de enero de 2024]. Report No.: {SWD(2021) 148 final}-{SWD(2021) 149 final} Disponible en: http://bit.ly/3KMLidq

Directiva 2004/37/CE del Parlamento Europeo y del Consejo de 29 de abril de 2004 relativa a la protección de los trabajadores contra los riesgos relacionados con la exposición a agentes carcinógenos o mutágenos durante el trabajo. Diario Oficial de las Comunidades Europeas, nº 158 (30-04-2004). Disponible en: http://bit.ly/3ZZJAtB

European Commission. Directorate General for Employment, Social Affairs and Inclusion. Guidance for the safe management of hazardous medicinal products at work. [Monografía de Internet]. LU: Publications Office; 2023 [citado 29 de enero de 2024]. Disponible en: https://data.europa.eu/doi/10.2767/361444

Poveda L, Zamudio, A, Sanz Villorejo, J, Cobos JL, Martínez de Aramayona Ma José, Muedra M, et al. Documento de Consenso de Sociedades Científicas. Seguridad del paciente y del profesional sanitario en la preparación y administración de medicinas peligrosas [Internet]. Madrid, España: Sociedades Científicas Españolas; 2015 [citado 15 de febrero de 2023]. Disponible en: https://goo.gl/gvzRST

The Hazardous Drug Consensus Group. Consensus Statement on the Handling of Hazardous Drugs: Per USP Chapter [Monografía de Internet]. North Carolina, USA: Hazardous Drug Consensus Statement; 2017 [citado el 29 de enero de 2024]. Disponible en: https://bit.ly/2qubr6V

Bernabeu-Martínez MÁ, Sánchez-Tormo J, García-Salom P, Sanz-Valero J, Wanden-Berghe C. Perception of risk of exposure in the management of hazardous drugs in home hospitalization and hospital units. Walton A, editor. PLOS ONE. 2021;16(7):e0253909. DOI: 10.1371/journal.pone.0253909

Descargas

Publicado

2024-01-28

Cómo citar

Bernabeu Martinez, M. Ángeles. (2024). Medicamentos peligrosos: resumen normativo. Hospital a Domicilio, 8(1), 29–36. https://doi.org/10.22585/hospdomic.v8i1.210

Número

Sección

Artículos especiales